Friday, October 30, 2015

EMKA & SCIREQ SPECIALIZING IN CARDIOPULMONARY SOLUTIONS

The American Heart Association’s Scientific Sessions is the leading US cardiovascular conference for basic, translational, clinical and population science. From vascular biology to genetics and drug discovery, the event will cover the full spectrum of cardiovascular disease from a variety of perspectives.

By promoting a collaborative approach to study both cardiovascular and pulmonary function together, emka & SCIREQ offer a unique perspective into the preclinical study of heart diseases. Our sophisticated instruments permit the collection and analysis of ECG signals, PV Loops, and lung function in vivo and ex vivo. This allows for detailed insights into many cardiovascular diseases, including but not limited to:

Heart Failure


Heart failure occurs when the heart muscle is weakened and cannot pump enough blood to meet the body’s needs. When the left ventricle is weakened, pressure increases in the lung vasculature allowing fluid to collect (pulmonary edema). When the right ventricle is weakened, it is often a result of pulmonary hypertension, where the pulmonary arteries are narrowed or damaged. This makes it harder for blood to flow through the lungs and forces the right ventricle to work harder, eventually weakening the muscle. Understanding this close interaction and impact on the body requires a two-step approach, investigating both cardio and pulmonary outcomes.

Read more on…

  • How to quantify changes in lung volume in a fully conscious subject while simultaneously acquiring ECG with the emkaPACK4G.
  • The effects of a weakening heart muscle with PV loop data and how to efficiently study contractility-relaxation on isolated hearts or atrial and papillary muscles.
  • The range of pulmonary outcomes accurately measured in vivo with the flexiVent and ex vivo with the emkaBATH.

    Arrhythmia



    Arrhythmia is a condition where the heart beats with an irregular rhythm, due to a change in the electrical impulses to the heart. These changes affect the heart’s ability to pump blood effectively, leading to other organs (e.g. the lungs) becoming damaged. Some arrhythmias like Respiratory Sinus Arrhythmia (RSA) are directly related to the pressure exerted on the heart by the inhalation and exhalation of the lungs.

    Read more on…

  • Quantifying and measuring the effects of cardiomyopathy or abnormal atrial and ventricular contractions with the emkaPACK4G in conscious and freely moving large animal subjects.
  • Obtaining accurate arrhythmia and behavior analysis using ECG in conscious and freely moving subjects with the rodentPACK2.
  • Simultaneously acquiring pulmonary, ECG and arrhythmia data on small animals using the ecgTUNNEL.
  • Extending your studies with QT interval analysis or perfuse the heart with a pro or antiarrhythmic agent with the isolated heart system.

    COPD

    Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory disease that causes obstructed airflow into and out of the lungs. Cigarette smoking is the leading cause of COPD, therefore most animal models are developed through smoke exposure over a significant period of time. The American Heart Association recognizes that cigarette smoking is one of the 6 major independent risk factors for heart disease, therefore these animal models of COPD will likely impact both cardiovascular and pulmonary systems and both endpoints should be studied.

    Read more on…

  • How to reliably develop in vivo disease models that mimic complex pathophysiological mechanisms of COPD using the inExpose, an automated platform for inhalation exposure..
  • Pressure-volume manoeuvers, forced expired volume and other endpoints of clinical translational value performed by the flexiVent.
  • How Whole Body Plethysmography can be an easy tool for screening subjects quickly for preliminary respiratory data with the option of delivering inhaled therapeutics.
  • Studying the underlying pathophysiology of COPD by measuring the structure and function of the lung, along with quantifying the effects of pulmonary hypertension and decreased vascularization with the flexiVent.
  • Delivering therapeutics while obtaining ECG and pulmonary data for rodents using the ecgTUNNEL.

    Learn more at booth 1214 in the main convention center hall. Our cardio and pulmonary equipment will be on display and our team of experts will be there to discuss how we can work together to optimize your research and answer any questions you may have.

    Exhibit hours:
    Sunday November 8 – 11 am to 4 pm
    Monday November 9 - 10 am to 4 pm
    Tuesday November 10 - 10 am to 2:30 pm

    For more information on our respiratory products, please visit the SCIREQ website: www.scireq.com.
    For more information on our cardiovascular solutions, please visit the emka TECNOLOGIES website: www.emkatech.com.
    Contact us: toll free at 1-877-572-4737 or by email at emka_SCIREQ@scireq.com.

  • Thursday, October 22, 2015

    LET’S TALK ABOUT IMPEDANCE.

    The current state-of-the-art in pre-clinical lung function measurements is the evaluation of the mechanical properties of the respiratory system using the forced oscillation technique. This technique, which is at the heart of the flexiVent system, derives from a classic engineering method of characterizing dynamic systems. In this approach, the respiratory system is probed with a specific test signal (e.g. air signal sent by the flexiVent piston), its response to the imposed input signal is captured via specific output signals (e.g. pressure changes), and the relationship between input and output signals is characterized using a transfer function that is referred to as impedance or, more specifically in the present case, respiratory input impedance (abbreviated Zrs).

    Respiratory input impedance is the primary outcome of a respiratory mechanics assessment using the forced oscillation technique. In the flexiWare software, it is obtained following the execution of a prime perturbation (e.g. Quick Prime-3) and is automatically calculated and graphically represented against the oscillating frequency of the input signal. Respiratory input impedance expresses a complex relationship between flow and pressure. This function has two separate components, resistance (upper graph) and reactance (lower graph), and captures the overall opposition of the respiratory system to the imposed perturbation.

    Impedance data can be rich in structure-function related information. However, in order to be meaningful, it needs to be physiologically interpreted. The interpretation can either be qualitative, via a detailed analysis of the curves and their frequency-dependent profiles, or quantitative, through the use of anatomically-based advanced mathematical models describing the mechanical behaviour of the lung.

    In pre-clinical research, while the former approach was used initially, the latter one currently constitutes the norm. The true power of this approach comes from the ability of the constant phase model to fit the entire impedance data and, through specific parameters, partition the response between airway and lung tissue mechanics. By doing so, the method provides a more straightforward access to the peripheral lungs than alternative techniques which are highly invasive, technically demanding and of low throughput.

    Please contact us to see how you can use the forced oscillation technique to its fullest potential to meet your research objectives or explore new scientific avenues.

    Phone 1.514.286.1429 | Toll Free 1.877.572.4737
    Email sales@scireq.com

    Read More:
    Bates, JHT, CG Irvin, R Farré, Z Hantos. 2011. Oscillation mechanics of the respiratory system. Compr Physiol 1:1233-1272.