The New Year has just started and already an impressive number of publications featuring the flexiVent are available. Amongst these first 2016 publications, we are proud to highlight one by a Canadian group of researchers whose findings could prove to be useful to outline disease mechanisms or investigate new therapeutic avenues:
BIOSIGNATURE FOR AIRWAY INFLAMMATION IN A HOUSE DUST MITE-CHALLENGED MURINE MODEL OF ALLERGIC ASTHMA. - Hadeesha Piyadasa, Anthony Altieri, Sujata Basu, Jacquie Schwartz, Andrew J. Halayko, Neeloffer Mookherjee. Biology Open 2016 : doi: 10.1242/bio.014464
The flexiVent - An Invaluable Tool
The study describes a list of biomolecules pertaining to the allergen most frequently associated with human asthma, house-dust mite, in a preclinical model. It also includes relevant physiological endpoints such as airway hyperresponsiveness, a key feature of asthma, which, in this paper, was assessed using a detailed lung function measurement method exclusive to the flexiVent system. This approach is based on a multi-frequency forced oscillation evaluation of the respiratory system which permits the partitioning of the response into airway and tissue mechanics. A refined level of model characterization can thus be obtained for a deeper level of understanding.
Please contact us for more information on how to incorporate detailed lung function measurements into your studies.
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