If your plans include attending the Society of Toxicology’s
52nd Annual Meeting, we invite you to visit us at booth 1128! While in San Antonio, discuss your studies
with our team, discover how our latest developments can impact your research
and experience our systems for pre-clinical inhalation exposure and lung
REFINING THE DOSE RESPONSE: STANDARDIZING THE CHALLENGE.
It is now easier than ever to compare inhaled challenges
across studies thanks to new features available in our software. Nebulizer
output may change over time and certainly varies from one substance to another. To address the variability, we have suggested
characterizing the nebulizer before and perhaps throughout experiments. The
latest version of our software includes a characterization procedure that
embeds the nebulizer output within the experiment data file. In addition, it
uses the results of the characterization to calculate delivered dose following an
inhaled challenge. The combination of these new features allows for further
refinement in how the data are reported and interpreted and provides a level of
standardization that was previously unavailable.
RESPIRATORY MECHANICS MEASUREMENTS IN CONSCIOUS DOGS AND PRIMATES
Following the preview available last fall at the SPS
conference in Phoenix, view and discuss results from our collaboration with Dr.
Simon Authier of CiToxLAB that aimed to test a novel approach (high frequency
airwave oscillometry) to measure airway resistance non-invasively in conscious
dogs and non-human primates while
recording conventional breathing parameters (e.g. tidal volume, respiratory
Results are promising for applications in large animal
toxicology studies as airwave oscillometry was well tolerated and more
sensitive than some conventional respiratory parameters to drug-induced
bronchoconstriction in non-human primates.
Learn more at the poster presentation on Monday, March 11th
from 1:00 pm - 4:30 pm.
Models—Measurements and Validation
Abstract #757, Poster Board #636
PRODUCT DEMONSTRATIONS AND DISCUSSION AT OUR BOOTH
When it comes to inhalation
exposure, SCIREQ offers the inExpose:
a precise, bench top inhalation exposure system with customizable turn-key
solutions from toxin generation to exhaust disposal, with real-time monitoring
and control features, as well as computerized data acquisition and analysis.
Its modular, compact form factor reduces direct and indirect costs, minimizes
unintentional dilution and is ideal for use in a standard laboratory, without
the need for a purpose-built facility.
Interested in respiratory
mechanics? Come see our flexiVent
with its Multi-Subject Extension (MSX). The flexiVent
system has long been considered the gold standard for pre-clinical respiratory
mechanics assessments. When used in combination with the MSX, it offers
distinct study design advantages and greatly increases the efficiency of
experimentation. The system will allow you to accelerate data collection and
expediently carry out time-sensitive studies.
Visit our booth to discuss aerosol challenges or lung
function measurements in conscious subjects, or for a demonstration of the inExpose or flexiVent. We look forward to speaking with you in San Antonio!
Monday, March 11 9:00 AM
- 4:30 PM
Tuesday, March 12 8:30 AM
- 4:30 PM
Wednesday, March 13 8:30 AM -