Procedure standardization often rhymes with a set of strict guidelines to be followed or defined protocol restrictions. This is however no longer the case for the preclinical assessment of airway hyperresponsiveness (AHR) using aerosolized contractile agonists.
Indeed, the missing key element in this widely performed procedure, the access to the dose of aerosolized agent delivered to the subject’s airways, is now available to researchers with the push of a button in the flexiVent’s operating software for a knowledgeable reporting and interpretation of results. The only requirement, in addition to the regular calibration of the system, is the characterization of the nebulizer output rate, which is known to vary from unit to unit, with usage, and time.
By easily taking into account protocol variations, the introduction of an automated delivered dose estimate will undoubtedly bring a valuable element of standardization to the technique of AHR. Contact us to find out how to improve AHR study comparisons and reproducibility.
Delivered dose estimate to standardize airway hyperresponsiveness assessment in mice. Robichaud et al. American Journal of Physiology-Lung Cellular and Molecular Physiology, 2015. DOI:10.1152/ajplung.00343.2014.
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