As everyone is getting on their way to the 12th Annual Meeting of the Safety Pharmacology Society, we would like to invite you to come by our SCIREQ booth No. 218 to get a hands-on impression of our systems for pre-clinical lung function measurement and inhalation toxicology.
Respiratory Mechanics for Safety Pharmacology
Our flexiVent system is widely used to obtain an accurate, highly detailed and specific assessment of respiratory mechanics using the Forced Oscillation Technique (FOT). However, the flexiVent is best known for its use in rodents, and it is perhaps less widely known that larger flexiVent modules are available to measure lung function in animals up to or potentially exceeding 10 kg, including primates and dogs.
Towards Conscious Measurements
In Safety Pharmacology, FOT measurements as obtained with the flexiVent to date have been limited to "second tier" measurements because they required passive, intubated subjects and hence necessitated anesthesia. However, we have now developed new technology that promises true respiratory mechanics measurements in conscious animals. In recent tests carried out in collaboration with Dr. Simon Authier at CiToxLAB in Montreal, we were able to measure airway resistance at baseline and following MCH injection in restrained, conscious dogs and primates. Only a glimpse of these data will be available at SPS, though, with a fully detailed presentation is scheduled for SOT 2013.
Come Join the Discussion
While our recent tests represent an important milestone, more work will be required to bring this technology to maturity. Nonetheless, we would like to invite you to stop by our SPS booth for more details on what we have achieved so far and what the next steps will be. A discussion with you in Phoenix will allow us to make sure that we further develop this exciting technology in a direction that best meets the needs of your application and of the Safety Pharmacology community at large. We look forward to talking to you!