Thursday, October 12, 2017

Workshop on Eosinophils in Allergy and Related Diseases – Tokyo, Japan

Will you be attending the 31st Workshop on Eosinophils in Allergy and Related Diseases in Tokyo? If so, come and meet with our partner emka TECHNOLOGIES Japan and see our solutions for your research.

Workshop Information
Date:         21st October 2017
Time:        10:00 am - 17:00 pm
Location:  Tokyo, Japan
Chairman: Dr. Hiroshi Nakajima, Allergy & Clinical Immunology, Chiba University
                 Hospital
Director:    Dr. Makoto Nagata, Allergy Center, Saitama Medical University


More information from previous workshops on this topic:

Tuesday, August 22, 2017

Deep inflations and their role in reproducible lung function measurements

Reproducibility is more than ever an inevitable topic in research.  Recently, the subject was addressed by Dr. Jason Bates1 specifically in relation to preclinical lung function measurements. 

As explained in this interesting article, lung function measurements are affected by a number of confounding factors and controlling for them ensures that the subjects are studied under the same conditions, which helps generate robust data that can be reproduced by others. 

According to Dr. Bates, controlled experimental conditions including anaesthesia and mechanical ventilation are needed to achieve high-quality preclinical lung function data1, 2.  However, it is known that under these conditions, there is a progressive loss in lung volume due to airway closure or collapse3.  Additionally, as can be seen in a number of studies, once closed, airspaces do not spontaneously re-open.  A high-pressure manoeuver, such as a deep lung inflation, is typically required to open-up closed airways4, 5 or completely collapsed lungs6.  Therefore, as reported in the article at hand1, it is key to start a preclinical lung function experiment with a deep inflation to standardize lung volumes across subjects at baseline. 

DEEP INFLATION

Technical Description
  • The deep inflation gradually inflates the subject’s lungs to a pressure of 30 cmH2O over a period of 3 seconds.
  • The lungs are then held at that pressure for another 3 seconds, time during the alveolar pressure is allowed to equilibrate to the applied pressure.
  • The initial and end volumes are used in the calculation the inspiratory capacity (IC).
Physiological Description
  • The Deep Inflation perturbation brings the subject’s lungs from end of expiration (FRC) to total lung capacity (TLC), which is defined by default as a pressure of 30 cmH2O.
  • It provides a direct measurement of the subject’s inspiratory capacity.
For more information on the deep inflation and other manoeuvers questions linked to preclinical lung function measurements or scientific equipment for respiratory research, please visit SCIREQ website - Knowledge Center or contact one of our applications specialists.  We will be happy to work with you to enhance the reproducibility of your research.

References
1.       Bates, JHT.  2017.  CORP: Measurement of lung function in small animals.  J Appl Physiol, in press, DOI: 10.1152/japplphysiol.00243.2017.
2.       Bates JH, Irvin CG.  2003.  Measuring lung function in mice: the phenotyping uncertainty principle. J Appl Physiol 94: 1297-306.
3.       Mead J, Collier C.  1959.  Relation of volume history of lungs to respiratory mechanics in anesthetized dogs.  J Appl Physiol 14: 669-678.
4.       Wagers S, Lundblad LK, Ekman M, Irvin CG, Bates JH.  2004.  The allergic mouse model of asthma: normal smooth muscle in an abnormal lung?  J Appl Physiol 96: 2019-27.
5.       Shalaby KH, Gold LG, Schuessler TF, Martin JG, Robichaud A.  2010.  Combined forced oscillation and forced expiration measurements in mice for the assessment of airway hyperresponsiveness.  Respir Res 11: 82.
6.       Limjunyawong N, Fallica J, Horton MR, Mitzner W.  2015.  Measurement of the pressure-volume curve in mouse lungs. Journal of visualized experiments: J Vis Exp 95: 52376.

Monday, August 21, 2017

WORKSHOP ON PHENOTYPING MOUSE MODELS OF HUMAN LUNG DISEASE

Do not miss the opportunity to learn key laboratory techniques used in respiratory research by attending the workshop on Phenotyping Mouse Models of Human Lung Disease hosted by the Jackson Laboratory. This workshop will take place from October 9-14, 2017 in beautiful Bar Harbor, Maine.
Participants completing this workshop will acquire a working knowledge of basic pulmonary biology and the pathophysiology/histopathology accompanying lung diseases. As in the past, SCIREQ’s Senior Scientist, Annette Robichaud will supervise some laboratory sessions on lung function measurements using state-of-the art techniques.

Hands-on laboratory sessions will cover: 
» Airway hyper-responsiveness (AHR) measurement using flexiVent
» Sampling techniques (lung lavage & bone marrow)
» Lung volume and pressure-volume (PV) curves
» Lung morphometry and stereology
» Pulmonary diffusing capacity
» Intubation and tracheostomy
» Lung histopathology


For additional information and to register, go to:
https://www.jax.org/Lung

Space is limited. Early enrollment is advised.

Thursday, July 27, 2017

15th International Symposium on Sleep & Breathing - THANK YOU!

We would like to extend a warm THANK YOU to the organizers of the 15th International Symposium on Sleep & Breathing that took place last week in Madison, Wisconsin and its participants. SCIREQ Inc. was proud to participate in this event and thus contribute to the next generation of leading scientists.


The Meeting’s Focus
The meeting’s tradition is a focus on trainees and junior faculty. Senior investigators sponsor junior investigators to present original research and receive constructive feedback. The most meritorious papers are selected for prestigious awards, including the Ann Suratt Award. The exceptional science presented never fails to generate animated discussions, which are further extended in an informal setting, as part of the evening social events where local history, music, dance and culinary culture are highlighted.1

Website:115th International Symposium on Sleep & Breathing.”The Meeting’s Focus” https://www.sleepandbreathing2017.org/history 

Monday, June 5, 2017

Thank you - ISAM 2017

SCIREQ attended the 21st International Society for Aerosols in Medicine (ISAM) Congress in Santa Fe. The event is focused on aerosol research, pulmonary drug delivery and inhalation toxicology. We demonstrated our respiratory research equipment with scientists, highlighting our new inExpose E-cigarette Research Extension

We thank the many researchers who came by to discuss their in vivo respiratory mechanics and inhalation exposure research.



Not at the conference? We are always available to answer any questions you may have. Please contact us at info@scireq.com or call us toll free at 1.877.572.4737. We also have a team worldwide who can help you with your research needs. Find out more by visiting our website: www.scireq.com/worldwide-distribution.




Wednesday, May 31, 2017

World No Tobacco Day

Every year, on 31 May, WHO and partners mark World No Tobacco Day (WNTD), highlighting the health and additional risks associated with tobacco use, and advocating for effective policies to reduce tobacco consumption.

The theme for this year's World No Tobacco Day is "Tobacco – a threat to development." It proposes measures that governments and the public should take to promote health and development by confronting the global tobacco crisis.1

  
The harmful effects of tobacco smoke exposure are well documented. Yet research is still necessary to understand the underlying pathophysiological mechanisms and there is a pressing need for new therapeutic agents to treat patients. Scientific evidence is also needed to understand the risks associated with vapour exposure from electronic cigarettes (e-cigarettes) in order to guide the decision-making process for the use of these nicotine delivery devices. The rapid adoption of e-cigarettes, especially amongst the youth, has spurred a rush to fill the knowledge gap pertaining to the safety profile for the users and the environment.

SCIREQ Related Products for
Tobacco Studies, E-Cigarettes & Vaping


The inExpose is a versatile, programmable, and compact exposure system that can be configured with smoke generation devices (e.g. cigarette smoking robot, single cigarette chamber, e-cigarettes), or nebulizers to generate a wide range of exposures consistently within and between studies, as well as across laboratories.

The E-cigarette extension is designed for the push button 3rd generation “MOD” e-cigarettes. This extension allows for longer exposures due to a larger tank, offers automated activation, custom puff profiles, and temperature control of the vapour produced.


The flexiVent system combines a wide selection of lung function measurements within a single device, while offering the sensitivity to capture small but significant changes. Overall and detailed respiratory mechanics, specific lung volumes, pressure-volume or flow-volume loops are examples of measurements used in tobacco or e-cigarette related studies with some outcomes (FEV, lung volumes) also having a translational value. 

To learn more about our products and how they may provide insight into tobacco related diseases or other applications, please contact info@scireq.com.

References 

1World Health Organization. "Tobacco - a threat to development" http://www.who.int/campaigns/no-tobacco-day/2017/en/

Tuesday, May 30, 2017

ATS 2017 - Thank you!

Thank you to everyone who visited our booth at ATS 2017 in Washington last week! It was a successful conference and we look forward to seeing you all again next year.




We also had a great time celebrating the 20th anniversary of the flexiVent during our yearly breakfast event.  A special THANK YOU to our presenters! It was due to their contribution, that the event was well attended and received very positive feedback. 


We are looking forward to future scientific and technological advances that will help researchers learn and better understand pulmonary function.

Your SCIREQ Team!