Monday, October 24, 2016

Thank you for meeting us at the 2016 Pittsburgh-Munich Lung Conference!

As it was our first time in attendance at the annual Pittsburgh-Munich Lung Conference, we would like to extend our thanks to the Division of Pulmonary and Critical Care Medicine at the University of Pittsburgh for such a warm welcome. The meeting was an excellent occasion to speak with current customers and other prominent researchers helping to improve our understanding of pulmonary immune response, inflammatory pathways and innovative approaches to treating respiratory disease.

Contact us to learn more about our suite of technology for respiratory research.

Phone 1.514.286.1429 | Toll Free 1.877.572.4737 | Email

Monday, October 3, 2016

At the Forefront of Preclinical Tobacco Research

Smoking has reached an epidemic proportion worldwide and its effect in terms of health-related issues is huge. While smoking prevention and cessation are key to bringing an end to this epidemic, scientific research is needed both to understand smoke-induced pathophysiological mechanisms and to develop novel therapeutic agents to treat patients. The smoking market is also changing, as seen with the introduction of new nicotine delivery devices, such as electronic cigarettes. Their rapid adoption has raised a lot of questions relating to the safety and benefits of these devices, most of which remain incompletely addressed at the present day.

Given the extended time period needed to generate sound scientific evidence, research on tobacco or tobacco-related products requires a joint effort. SCIREQ is proud to be part of these efforts by offering state-of-the-art equipment for basic in vivo and in vitro studies. Particularly well adapted to generate consistent and reproducible exposure environments is the inExpose system, a versatile and programmable exposure system that can be configured with several smoke and vape generating devices. The impact on the respiratory system can then be assessed using invasive and non-invasive lung function measurement techniques. Sitting at the forefront, the flexiVent system offers a variety of lung function measurements to address specific questions or gain novel insights. These accurate and detailed measurements can be complemented by the non-invasive barometric monitoring of the ventilation profile or disease symptoms (e.g. cough) throughout a study, which can involve repeated exposure sessions over several months. Finally, any direct effect on either airway or vascular smooth muscle can also be evaluated in absence of external influences using tissue baths for an overall meaningful and far-reaching assessment.

Please contact us to find out more or visit our website at

Tuesday, May 24, 2016

Thank you ATS!

Thank you to the American Thoracic Society (ATS) conference organizers for another wonderful event! Our team is heading back to the office and are looking forward to continuing the discussion with all the researchers we met at our booth.

E-cigarette research

We had a wonderful Breakfast Symposium last Monday where guest speaker Dr. Laura Crotty Alexander1, SCIREQ's Vice-President Mr. David Brunet and Senior Scientist Dr. Annette Robichaud discussed what is known about e-cigarettes and what is left to be discovered and how researchers might work together towards standardization of the various parameters used to assess the impact of these devices. Many researchers gathered to share their knowledge and to begin answering some questions. Everyone agrees that more work needs to be done before we can have a clear understanding of the impact of e-cigarettes - an industry that it changing at a fast pace.

Lung volumes

The flexiVent is now capable of providing more measurements of lung volumes. The newest additions include measurements of the total and residual lung volumes (TLC/RV). As with other techniques, this is done using a computer-controlled automated manoeuvre for standardization and control of parameters. The acquisition of these new outcomes does not require the use of a separate device and can easily be preceded by comprehensive respiratory mechanics measurements typically performed with the flexiVent. Lung volume changes are sensitive to physiological or pathophysiological changes.

SCIREQ's Senior Scientist, Dr. Annette Robichaud, and R&B manager, Ms. Liah Fereydoonzad, presented their poster at ATS entitled "Automated full range pressure-volume curves in mice & rats2" which found that the automated method of constructing full range PV curves in mice proved to be equivalent to the classic, manually operated, syringe pump method. The automation of the technique alleviates some of the weaknesses of the classic technique while bringing simplicity and standardization.

To learn more on the flexiVent and the lung volumes technique, visit our website at

1Dr. Laura Crotty Alexander is a researcher and staff physician in the VA San Diego Healthcare System and Assistant Professor at the University of California at San Diego (UCSD). She obtained her doctorate degree of medicine (M.D.) from Duke University and trained in internal medicine at the Massachusetts General Hospital. She then stayed in the Boston area and completed a Pulmonary and Critical Care fellowship training at the Harvard Medical School before moving to UCSD for a post-doctoral fellowship. She obtained a VA career development award via her research in asthma, and accepted a faculty position at UCSD in 2011.

Dr. Crotty Alexander has authored many publications on electronic cigarettes and is a leader in this field of research.

2Automated full range pressure-volume curves in mice & rats - Robichaud A et al. PDF version on SCIREQ website

Thursday, May 19, 2016

inExpose featured in recent Nature publication

Congratulations to Dr. Blackwell's team at Vanderbilt University who recently published in Nature Communications1!

As you may know, chronic obstructive pulmonary disease (COPD) is characterized by obstruction in airflow, chronic inflammation, and destruction of the alveolar tissue. This group from Vanderbilt University hypothesized that secretory immunoglobulin A (SIgA) deficiency contributes to chronic airway inflammation and COPD disease progression.

The SCIREQ inExpose was utilized in multiple ways to gather evidence to support their theory. First, using the inExpose to deliver cigarette smoke, researchers confirmed that (SIgA) knock-out mice spontaneously develop COPD-like symptoms with similar severity to cigarette smoke exposed subjects.

Next, a lysate from a non-typeable Haemophilus influenza (NTHi), which is commonly found in COPD patients, was prepared as an aerosol solution and delivered using the inExpose to both wild-type and knock-out mice. The group then re-introduced SIgA and found an attenuated inflammatory response, suggesting SIgA limits the response to bacterial antigens in the respiratory system.

To learn more and read the full publication, visit Nature Communications' website at

Whether through smoke or aerosol, nose-only or whole body exposure, the inExpose easily adapts to various toxicology research needs by permitting relevant and reproducible inhalation exposure models. To learn more on this product, please visit our website at

1Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency Richmond BW et al. Nat Commun. 2016 Apr 5;7:11240. doi: 10.1038/ncomms11240.

Tuesday, April 26, 2016

Japanese Respiratory Society's annual meeting with a global focus

We were delighted to see a global presence at the 56th Annual Meeting of the Japanese Respiratory Society (JRS) conference in Kyoto Japan. The conference, themed "Pulmonary medicine 2016, Developing Intellectual and Future Innovations", featured ATS/ERS/JRS/APSR Inter-Assembly Symposiums that aimed to promote basic lung research and strengthen exchanges with academic societies overseas.

Many International speakers were invited as lecturers to highlight important progress being made in the field of respiratory research. Key International symposiums included:

  • Update on lung cancer
  • Inter-assembly symposium on Allergy, Immunology and inflammation
  • Inter-assembly symposium of Respiratory Cell and Molecular Biology
  • Update on COPD pathogenesis and therapy
  • Update on asthma pathogenesis and therapy
  • Update on Pulmonary Fibrosis and therapy

    Mr. Eiji Iwane and Shota Inoue, emka & SCIREQ's representative in Japan, and SCIREQ's Vice President Mr. David Brunet met with researchers and delegates from the various respiratory societies, taking part in this international collaboration first hand.

    We loved Japan and hope all JRS attendees enjoyed its amazing culture, food and views of Sakura cherry blossom trees. We hope to see you in Tokyo next year.

    Related links:

  • Japanese Respiratory Society (JRS)
  • American Thoracic Society (ATS)
  • European Respiratory Society (ERS)
  • Asian Pacific Society of Respirology (APSR)

  • Thursday, March 24, 2016

    Meet with us in San Diego at Experimental Biology!

    Our team of Application Specialist are traveling to sunny San Diego next week to attend the Experimental Biology conference yet again! We will present and demonstrate our solutions for physiology, pharmacology and toxicology research. Take advantage of our presence to discuss your research and how emka & SCIREQ can provide solutions for your studies.

  • Detailed, reproducible and accurate data with the flexiVent, the gold standard for in vivo lung function measurements.
  • Inhalation exposure studies with e-cigarettes, heavy metals, environmental pollutants, occupational hazards and more using the inExpose.
  • tremoFlo for detailed lung function measurements in conscious large animals that go far beyond the guideline.
  • Plethysmographs for control of breathing and other conscious respiratory measurements.

    Click here to schedule a meeting with one of our respiratory specialists during EB 2016.

    Exhibit hours:

    Sunday April 3 - 9am to 4pm
    Monday April 4 - 9am to 4pm
    Tuesday April 5 - 9am to 4pm

    Contact us!

    Phone 1.514.286.1429 | Toll Free 1.877.572.4737

  • Tuesday, March 8, 2016

    emka & SCIREQ at ToxExpo 2016 in New Orleans!

    We will present and demonstrate our solutions for physiology, pharmacology and toxicology research. Take advantage of our presence to discuss your research and how emka & SCIREQ can provide solutions for your studies.

  • Inhalation exposure studies with e-cigarettes, heavy metals, environmental pollutants, occupational hazards and more using the inExpose
  • tremoFlo for detailed lung function measurements in conscious large animals that go far beyond the guideline.
  • Plethysmographs for conscious toxicology studies compliant with ICH S7A Guidelines & GLP

    As experts in respiratory safety pharmacology and toxicology emka & SCIREQ offer a suite of precise preclinical instruments for ex vivo and in vivo studies. Talk to our experienced team at SOT ToxExpo 2016 in New Orleans, LA at booth 1439, during posters and scientific sessions. Take advantage of our daily live demos to learn more about our products and services which include GLP guideline compliance.

    Booth 1439

    Exhibit hours:
    Monday March 14 9:15am to 4:30pm
    Tuesday March 15 9:15am to 4:30pm
    Wednesday March 16 9:15am to 4:30pm

    Contact us to schedule a meeting at our booth!

    Phone 1.514.286.1429 | Toll Free 1.877.572.4737