Bronchopulmonary dysplasia (BPD) is a pediatric respiratory disorder that affects preterm infants who experienced respiratory distress. The distress can be treated with artificial surfactant administration and hyperoxia which leads to impaired growth of the lung due. BPD will begin to manifest as inflammation and vascular changes in the lungs1.
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A common model of preclinical BPD uses hyperoxic exposure an early stage of life to alter the development of the subject’s lungs. Using conscious, unrestrained term or preterm subjects in a whole body plethysmography chamber allows for longitudinal measurements of ventilatory parameters, while also enabling controlled mixing and delivery of gases to generate a reproducible hyperoxic environment. Whole body plethysmography provides an ideal set-up to generate a model and track changes in the ventilatory parameters simultaneously.
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The emka & SCIREQ team will be attending the American Thoracic Society’s 2017 conference in Washington, D.C.! Come visit our booth #1731 and speak with our experienced team about our solutions for preclinical pediatric research.
1 Caffeine Prevents Hyperoxia-Induced Functional and Structural Lung Damage in Preterm Rabbits – Toelen et al. Neonatology. 109:274, 2016
2 Characteristics of asthma and airway hyper-responsiveness after premature birth – Oymar et al. Pediatr Allergy Immunol., 16: 487, 2005
3 Neonatal Hyperoxia Causes Pulmonary Vascular Disease and Shortens Life Span in Aging Mice – O’Reilly et al. Am J Physiol., 17:2601, 2011
4 Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor – Abman et al. Am J Physiol Lung Cell Mol Physiol. 283:L555, 2002
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