In patients suspected of a respiratory disease, the confirmation of a clinical diagnosis is often established following functional tests that can include spirometry, specific lung volumes/capacities, or both. As in humans, the characterization of a disease model or novel therapeutic approach at the basic science or pre-clinical level could also potentially necessitate functional measurements of various nature to convincingly confirm a respiratory phenotype.
Did you know?
The flexiVent was the first commercial device to
measure respiratory mechanics using the forced
oscillation technique in animals.
Pre-clinical lung function tests frequently involve an assessment by forced oscillation. This provides precise and detailed measurements that are undisputed to characterize the mechanical properties of the respiratory system. In some cases, it could be desirable to complement this evaluation with other disease sensitive outcomes or conditions to gain further insight either on the underlying mechanisms or the potential of the tested disease model or therapeutic approach at translating into something of clinical relevance.
As shown in some recent publications1, 2, combined measurements can seamlessly be done within the same subjects and experiment using a single device - the flexiVent. In these specific studies, forced expiration and lung volume measurements were performed in combination with a respiratory mechanics assessment to further characterize a number of disease models at baseline and/or following bronchoprovocation1 or to broaden the evaluation using various lung volumes and capacities2.
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1Devos, FC et al. 2017. Forced expiration measurements in mouse models of obstructive and restrictive lung diseases. Respiratory Research 18: 123.
2Robichaud, A et al. 2017. Automated full-range pressure-volume curves in mice and rats. Journal of Applied Physiology 123: 746-756.
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